Cost-Effectiveness Analysis of Newborn Screening for Severe Combined Immunodeficiency (SCID)
نویسنده
چکیده
Early detection of severe combined immunodeficiency (SCID) followed by prompt treatment is critical for affected babies to live healthy lives. Newborn screening (NBS) for SCID using the T-cell receptor excision circle (TREC) test has been being performed in California for two years and around 1 million babies have been screened there. The test has demonstrated high specificity and sensitivity in the early identification of the affected babies. While the essential medical benefit of identifying SCID infants early rather than late has been proven in several studies, less salient is the potential cost benefit of screening.
منابع مشابه
Cost-Effectiveness/Cost-Benefit Analysis of Newborn Screening for Severe Combined Immune Deficiency in Washington State.
OBJECTIVE To evaluate the expected cost-effectiveness and net benefit of the recent implementation of newborn screening (NBS) for severe combined immunodeficiency (SCID) in Washington State. STUDY DESIGN We constructed a decision analysis model to estimate the costs and benefits of NBS in an annual birth cohort of 86 600 infants based on projections of avoided infant deaths. Point estimates a...
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Newborn screening for severe combined immunodeficiency (SCID) is currently being performed in many states. It is important to address diagnostic challenges while outcomes are emerging from the first several years of screening. We present the case of a premature infant whose initial newborn screen was strongly positive for SCID. Subsequent lymphocyte subset analysis by flow cytometry was difficu...
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Severe combined immunodeficiency (SCID) is a group of syndromes resulting from genetic defects causing absence in T-cell and B-cell function, leading to serious and life-threatening infections. SCID is often fatal in the first 2 years of life if not identified and properly treated. While additional laboratory methods are being developed, the current T-cell receptor excision circle assay has pro...
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Newborn screening for severe combined immunodeficiency (SCID) is currently being performed in many states. It is important to address diagnostic challenges while outcomes are emerging from the first several years of screening. We present the case of a premature infant whose initial newborn screen was strongly positive for SCID. Subsequent lymphocyte subset analysis by flow cytometry was difficu...
متن کاملChallenges of newborn severe combined immunodeficiency screening among premature infants.
Newborn screening for severe combined immunodeficiency (SCID) is currently being performed in many states. It is important to address diagnostic challenges while outcomes are emerging from the first several years of screening. We present the case of a premature infant whose initial newborn screen was strongly positive for SCID. Subsequent lymphocyte subset analysis by flow cytometry was difficu...
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